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<div class="next-level"><a href="/search/result.php?tc=1.A.100.3">View Proteins belonging to: <span style="color:maroon;">The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family</span></a></div>
<!-- <div class="title">1.A.100: The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family</div> -->
<div class="description"><p style='text-align: center;'><strong>1.A.100 The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family&nbsp;</strong></p>
<p>Viruses belonging to the family Rhabdoviridae infect a variety of
different hosts including insects, vertebrates and plants. There are over 200 rhabdoviruses isolated
around the world.&nbsp; The complete genome sequence
and predicted transcription strategy of Wongabel <span class='highlight'>virus</span> (WONV), a&nbsp; rhabdovirus isolated from biting
midges (<em>Culicoides austropalpalis</em>) is available. The 13,196 nucleotide genome encodes five typical
rhabdovirus genes N, P, M, G and L, plus three genes located between the P and M genes (U1, U2, U3) and
two overlapping the N and G genes (U4, U5). The U5 gene product has characteristics
typical of viroporins with structural similarities with the
alpha-1 <span class='highlight'>protein</span> (putative viroporin) of viruses in the genus Ephemerovirus, and similarity with the <span class='highlight'>avian</span>-associated Flanders <span class='highlight'>virus</span> has been noted (<a class="reflink" href="/search/result.php?tc=1.A.100#ref34544547">Gubala <em>et al.</em> 2008</a>).&nbsp;</p>
<p>Viroporins are viral ion channel proteins usually with 50-120 amino acids.&nbsp; They play important roles in regulating virus replication, including virus entry, assembly and release. They may also modulate the electrochemical
balance in subcellular compartments of the host cells. <a class="reflink" href="/search/result.php?tc=1.A.100#ref34550060">Wang <em>et al.</em> 2011 </a>summarized advances concerning&nbsp;
viroporins, including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7,
picornavirus 2B, and the coronavirus E and 3a viroporins with emphasis on their function s
and mechanisms.</p></div>
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<div class="next-level"><a href="/search/result.php?tc=1.A.100.3">View Proteins belonging to: <span style="color:maroon;">The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family</span></a></div>
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<h4>References associated with 1.A.100 family:</h4>
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<A ID="ref34544547"></A>Gubala, A.J., D.F. Proll, R.T. Barnard, C.J. Cowled, S.G. Crameri, A.D. Hyatt, and D.B. Boyle. (2008). Genomic characterisation of Wongabel virus reveals novel genes within the Rhabdoviridae. Virology 376: 13-23. <A HREF="" target="_window">18436275</A></div>
<div class="ref">
<div class=''>
<A ID="ref34550060"></A>Wang, K., S. Xie, and B. Sun. (2011). Viral proteins function as ion channels. Biochim. Biophys. Acta. 1808: 510-515. <A HREF="" target="_window">20478263</A></div>
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